I have been taking low-dose naltrexone since February, in the hope that it will help me cut down the prednisone. So far, it has not done that, but for many patients LDN takes 6 months to a year to make a difference (and for some, it never works). Meanwhile, my neuropathy and sciatica have disappeared, and I feel optimistic, so I'm a big fan of LDN. Unlike MTX, LDN will not hurt you.