I was on the big 3 for 9 months but had eye problems so they took me off ethambutol. I continue to take azirhromycn and rifampin. I have had restless leg for years and finally have found a med that works. I took 4mg of ropinirole at supper time. Four months ago it was not enough as if I sat down for a period of time during the day the restless leg would start. I didn't want to take my 4mg does of meds during the day as it made me sleepy. So now I take 1 mg of ropinirole as needed during the day and 4mg at supper time. I believe sleepless leg is hereditary as my brother has it and I suspect my father had it as well.