gamaryanne - Though experiencing increasingly severe neuropathologic side-effects from Oxaliplatin, I believe the primary reason for discontinuance of Folfirinox is the growing intensity of allergic/anaphylactic-like at the end of every infusion, Those symptoms include tongue thickening, extreme difficulty/inability to swallow, inability to pronounce/speak clearly, hyper-salivation, diminished cognition, difficulty ambulating, etc. Last time around the infusion team had to intervene with several meds, which I think included IV Atropine, Benadryl, steroids, and Pepcid. The PA in the room had Epinephrine on hand if the other meds weren't effective enough. I've had similar reactions near the end of all four infusions, but this was the worst.

Regarding platelets. Mine are within normal limits and are not a concern at this time.

Thanks for your input. Best wishes to you.