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Changing chemo regimen after 4 cycles of Folfirinox?

Pancreatic Cancer | Last Active: Aug 10, 2023 | Replies (20)
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@gamaryanne

Not sure of your actual symptoms but guessing they want to stop due to your chemistry or hematology. I did 12 rounds 2022 with extra fluids and Neulasta shot when pump was pulled. My platelets were the constant concern and I did get infusions 2 or 3 times. It worked miraculously for me. Perhaps a good match for KRAS mutation? I am also surviving a stage IV diagnosis.
Just now trying GEMZAR for a small reoccurrence in my liver. We will see if it works as well.
Perhaps there is a center of excellence closer to make your travel easier? Arizona, California, Madison, Wis; Colorado?

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Replies to "Not sure of your actual symptoms but guessing they want to stop due to your chemistry..."
wjk | @wjk | Jul 29, 2023

gamaryanne - Though experiencing increasingly severe neuropathologic side-effects from Oxaliplatin, I believe the primary reason for discontinuance of Folfirinox is the growing intensity of allergic/anaphylactic-like at the end of every infusion, Those symptoms include tongue thickening, extreme difficulty/inability to swallow, inability to pronounce/speak clearly, hyper-salivation, diminished cognition, difficulty ambulating, etc. Last time around the infusion team had to intervene with several meds, which I think included IV Atropine, Benadryl, steroids, and Pepcid. The PA in the room had Epinephrine on hand if the other meds weren't effective enough. I've had similar reactions near the end of all four infusions, but this was the worst.

Regarding platelets. Mine are within normal limits and are not a concern at this time.

Thanks for your input. Best wishes to you.

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