Biopsy report;
Based on guideline gastric carcinoma version 2.1 (2016) and oesophageal carcinoma 3.0 (2010)

Clinical Data and Macroscopy
Histological biopsy(s): esophagus
Type of acquisition mode: targeted from visible lesion
Number of esophageal biopsies: 5

Microscopy
Tumor type (WHO): adenocarcinoma nos
Degree of differentiation: grade 3
Mucous membrane esophagus: columnar
Intestinal metaplasia: not present
Active inflammation: severe

Additional research MMR/MSI
MLH1 loss: no
PMS2 loss: no
MSH2 loss: no
MSH6 loss: no

(Immuno)histochemistry
Other immunos / stains
PAS-D: positive
CDX2: focal positive
HER2 Immunohistochemistry: negative (score 0)
Status HER2: negative
PD-L1 test: 22C3
Number of tumor cells: = > 100 cells
Shape: Dx kit manufacturer
Tumor cells (TC): negative (< 1%)

Supplement microscopy
All tumor cells are strongly positive for PanCK, EBER is negative.

Some mucus vacuoles in the PasD.