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Stage 4 metastasis prostate cancer: Anyone had Lupron shots?

Prostate Cancer | Last Active: Jul 31, 2023 | Replies (205)
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@benice268

A 64 old with GS 4+3 T3B. Overall health. Dr said cancer is aggressive. After prostatectomy surgery in April, he said cancer escaped to seminal vesicle. PSA is rising from 0.047 in June to 0.067 in July. Oncology suggests ADT & Radiation treatment now. Can't do PSMA scan as PSA is undetectable now. ADT is for 18-24 months with Trelstar injection & bicalutamide pills; Radiation: 5 days/wk for 20 days. Not sure what side effects from these drugs (anyone knows??). Should wait for PSA to be detectable (>=0.1) to see if cancer spreads or do the ADT & Radiation treatment now? ..... Now I know how people in this community feel when it comes to make such big decision.

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Replies to "A 64 old with GS 4+3 T3B. Overall health. Dr said cancer is aggressive. After prostatectomy..."
edmond1971 | @edmond1971 | Jul 26, 2023

I'm convinced that the family of ADT drugs have the same side effects as they are all working to reduce testosterone.

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michaelcharles | @michaelcharles | Jul 27, 2023

I think that you are on the right (and unfortunate) path.
Jan 17, 2023 webinar from PCF.org; prominent Med Onc & Rad Onc discussing rising PSA after Tx.
Med Onc said he takes note of rising PSA over .03. They are initiating salvage tx sooner than later, and based on individual case. And not waiting necessarily for PSA to rise further.
Suggested that earlier intervention in aggressive disease may be of greater benefit.
At least that was my takeaway.
I failed 1st postop 90 day PSA @ 0.19. Pathology reported G 9 and EPE.
After a false start, tx initiated w/in 3 mos; IMRT to whole pelvic region (WPRT) and ADT.
Note: My ADT course was short; 4 mos. Not entirely sure why, but center of excellence tx plan for me. Waiting for 6 mo post salvage tx PSA verdict in Nov.
Length of ADT may be something to revisit/confirm after tx initiated, and depending upon your response to the ADT.
Prayers and best wishes to you and to all.

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cesar52 | @cesar52 | Jul 28, 2023

I have a very aggressive PC. Gleason 9. I would go ahead with ADT and radiation if I were in your situation. No need to wait until cancer spreads. ADT has nasty side-effects but kept me alive. Is not that the main reason we fight? Take care. Wish you the best.

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