Yes, Lupron is a bitch. I’ve been on for a little over five years and also take a Zytiga with prednisone. It has kept me alive so I have learned to live with all its side effects and I think I’ve had most of them. After five years, my PSA has finally started to rise slowly took eight months to get from undetectable to .5 did a PSMAA scan had 2 small optics one in my scapula one and a rib radiologist said too small to radiate so I’m waiting to see if they grow. They are keeping me on ADT bc they are not sure if I am really castrate resistant. So maybe ADH is still working.