Hello @plshouse1. The more common side effect from Neulasta is the bone pain that can happen for several days. I just read a previous reply of yours talking about the pain associated with this. I don’t know where you are on your chemo rounds but if you get another shot of Neulasta ask your oncologist if it’s ok for you to take over-the-counter Claritin antihistamine!
(not Claritin D) That is one of the best ways to mitigate the pain and discomfort. My oncologist told me to take it and we have a discussion on Connect with other members saying the same thing, that their oncologist suggested Claritin.

~Talk to me about Neulasta experiences: https://connect.mayoclinic.org/discussion/talk-to-me-about-neulasta-experiences/

Instead of the Neulasta being the culprit for your weakness, brain fog and fatigue could it be the chemo itself? All of those can be pretty common side effects of the chemotherapy as it also knocks down the blood counts as well as cancer cells. The impact of the chemo may be bothering you more each month as your treatments progress because each month it can take a little longer to bounce back. That’s probably why your doctor gave you Neulasta this month to help ramp up your white blood cell production.

I really can empathize with how you feel. It’s just draining mentally to be so fatigued and not feeling normal. But it’s a means to fighting the cancer and our bodies have amazing recuperative abilities. So hang in there and get through the treatments…then the healing can begin. There’s no guilt for lying around reading, binging on movies or listening to music. ☺️ But do try to walk several times daily…doesn’t have to be far and drink plenty of water to keep the toxins flushing through.

Do you have more chemo ahead?