Prolia side effects-increased RA inflammation

Colleen,
To be sure I'm understanding how this works, are my comments reaching out to all members or are you the only one who can see this? I hope it's to everyone so that something I say may help someone. Also, when I clicked on the above link for the fellow member, I did not see an option to post a comment.
In response to your question about continuing with Prolia, I have since read that people with weakened immune systems like me, are advised not to take Prolia, because of the side effects.
I was never told this by the doctor prescribing it or my Rheumatologist.
I don't have plans to continue this drug, but I'm also very concerned about being more prone to fractures if I stop taking it and if this is even true.
I am taking bone builder supplements from my primary care physician, who is also Integrative Medicine. He also ordered PT for strengthening. However, I have had so much pain in my legs from the Prolia I have not felt much like doing the exercises. And walking is still painful.
To make things worse, I have had to increase the Prednisone to help me with the pain and inflammation until another drug I agreed to try, Leflunomide, starts working, which can take 3 months. I am completely overwhelmed and am just praying continually and I know that God will open the right door.

After my first injection if Prolia, I started having severe leg pain when walking outside, and had to stop every 5-10 minutes because the pain was so bad. The pain has gotten much better now, since the drug must be wearing off, but I am due for another injection and feel pressured by my MD to take another one. However, two pharmacists I know very well, have warned me that the bad leg pain is a red flag. Has anyone experienced this with Prolia? I am terrified the leg pain will start again.

After my first injection if Prolia, I started having severe leg pain when walking outside, and had to stop every 5-10 minutes because the pain was so bad. The pain has gotten much better now, since the drug must be wearing off, but I am due for another injection and feel pressured by my MD to take another one. However, two pharmacists I know very well, have warned me that the bad leg pain is a red flag. Has anyone experienced this with Prolia? I am terrified the leg pain will start again.

Donna, your story is similar to mine. However, after the first six months and pain lessening as I got closer to needing the second injection I talked myself into getting the second injection because I did think I should give the Prolia a chance because I did believe it could help my bones. So after the second injection the leg pain and inflammation did come back. I concentrated on stretching and trying to eat less. Although none of that took away pain it helped getting through it. I now have less pain because I’m at month four before needing the third injection. I wish I knew if it was helping my bones. Yet I’m told I have to go through this another year before we can compare to another test. When I complain of pain to my endocrinologist she also dismisses it. I’m wondering if it is because of the double edged sword theory? Maybe the pain is a side effect of the bone improving? I honestly don’t know. I don’t think doctors know for sure. I think they just try to allow us to last longer as we age because it is what we want. I get up everyday and try to move around enough to keep me functional. I rest several times a day. I sleep well most nights and just keep plugging along. If this Prolia proves to be helping my bones after another year then I’ll know if it’s worth it. Everyone has a different situation. I’ll just keep trying. Good luck in making your decision. It certainly is not easy.

I have been on Prolia for 3 1/2 years, coming up on my 4th shot. I have started having hip, groin and thigh pain and wonder if it is from the Prolia. When I ask the nurse paractioner he says not from Prolia but I still wonder. I am thinking of going to a Endocrinologist.

I do not remember being told once you start Prolia you can never go off, wish I had know

I do not have RA, however, I had increased inflammation (bursitis) in both hips since being on Prolia and now have an issue with popping in my low back. I never had these issues before taking the Prolia.

IF you have to take another drug to fight the side effects of the first one, than there is something wrong with that drug to begin with! I hate how the pharmaceutical industry just doesn't care...it's more money in their pocket to keep making more drugs. You end up worse than you started, or just different problems.