I have taken Prolia for 2 years and currently on a years vacation for Kidney issues which apparently not caused by Prolia. I had great results in that I went from Osteoporosis to Osteopenia within those two years and gained 1/2 inch in height. I had no side effects at all and will most likely go back on it. You must take calcium supplements and Vit D supplements and have blood within 2 weeks of the injection. Shot is not painful and needs to be done in a Dr. office. Good luck