Jim. The Jansen Clinical Trial was for guys with aggressive CR. PC. that had not distantly spread. I had Gleason 9, no other major health issues and I qualified. The trial routine was 6 months ADT plus Erleada or a placebo one month break for RP, then 6 more months of Erleada or the placebo. One of the side effects of Erleada is increased blood pressure which I got and which told me that I was on Erleada and not the placebo. I have been in the clinical trial for 20 months. If and when my PSA increases, I have been advised that I would be back on ADT and Erleada for as long as it remained effective and as long as the side effects were livable. I am fortunate to be in the clinical trial although having PC messes with my mind and my body. Good luck to all of the people here.