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@mahmudhasan

Condition you describe is very similar to mine. I even have a colostomy bag now as diversion for the pelvic floor dysfunction. But I still have slow transit constipation which is not relieved by OTC laxatives e.g. Miralax, MOM, senokot. Amitiza or Linzess didn't work for me. Have you had any results with Trulance or Motegrity?
Any insights you can share will be greatly appreciated.

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Replies to "Condition you describe is very similar to mine. I even have a colostomy bag now as..."

Have you tried lightening up on what you eat? Beef, pork, and poultry may take a while to digest, which may translate to slow transit. Fin fish may digest (and transit) quickly.

Also, cooking your produce to make it easier to digest, which could help speed transit. Think soup and well-cooked stir-fries as examples.

Also, have you tried avoiding processed foods, like cookies and crackers? Processed foods and even gluten could be a problem.

Have you looked at your meds and supplements to see if any could slow transit? I know fiber can slow transit. Miralax doesn't work for everyone. Senokat can be harsh.

Soluable fiber supplements slow transit time, especially if they say they help people lose weight (by slowing transit time).

And though it is counter-intuitive, have you tried minimal in-soluable fiber? One study showed huge improvement if patients stopped loading up on fiber, the thought being that in-soluable fiber just puts more "stuff" to transit into your colon.

Lastly, have you thought of a lubricant laxative like mineral oil? A bit of "slip" may do wonders.