The big three are Rifampin, Ethambutol, and Clarithromycin or Azithromycin. ( either). Terri was on alternating meds 2weeks per month of doxycycline and then ciprofloxacin. One month the Doxy and the next Cipro. My ID doctor put me on those as I had issues with the Big 3. I think I took those for about a year. A susceptibility test was done and my MAC wasn’t susceptible to the Cipro. It was then that I started on the Arikayce and am now MAC free. Unfortunately I now am fighting invasive aspergillosis fumagatos with pneumonia which is a whole other ball of wax - or mold really !! C’est la guerre. Hope that answers your question. Irene5