Sounds like you are having the same kind of severe cramping I had shortly after my first Lupron shot. While picking up another RX at Walgreens in Durango, CO in early July I asked the pharmacist if there was anything that I could get to help leg cramps/pains. He asked me to tell him more about the leg pain. I reported my Lupron injections and also the 2nd generation drug Nubeqa that I was taking. He then told me he was a oncology pharmacist for 8 years. During his time in that clinic they studied leg cramps from Lupron - since most patients had them. However; there was a smaller group of Lupron recipients that did not. He said upon investigation of the non-leg cramps group they learned that they were all taking antihistamines. I had been taking Allegra right up to my first Lupron shot in early April, but quit since it was for a seasonal allergy. He suggested I restart the Allegra - I did and have had no leg cramps or pains since. A friend whose also getting Lupron visited me for a week about the same time and I suggested as of his second day after a night of leg cramps that he try the Allegra. His cramps also ceased and now two weeks post have not returned as long as he takes the antihistamine daily. I hope this works as well for you.