← Return to Has anyone had PC that is very aggressive and a very low low PSA?

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@brownsf

Sounds like your doctor felt something suspicious during the DRE which led to the biopsy. And, like me, you were very lucky that a 4+4 Gleason cancer was discovered and you’re doing OK.

I would say the DRE plus PSA together are the gold standard. Most of the time, Prostate cancer is first detected by a PSA test and the DRE may be negative. But for a small but significant number of men like us, the PSA is relatively low but the DRE is positive.

Many so-called experts have come out against the DRE and even against the PSA for reasons I can’t understand. Neither test is expensive, presents risks, has side effects or is costly. Their main argument-they can lead to more invasive tests which may not be necessary. This could happen…but today there are other relatively non invasive tests which can help eliminate false positives before a biopsy is needed, so the argument that an elevated PSA or suspicious DRE leads straight to the operating room just doesn’t make sense.

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Replies to "Sounds like your doctor felt something suspicious during the DRE which led to the biopsy. And,..."

DRE relies on human interpretation. Machines are so much better than humans in most cases now.

Get an MRI.