@emo thanks Ive read About the yale arricle when it esa published. I can ask my doctor at Mayo About it. More than 7 years ago I used low dose naltrexone for pmdd. It didnt work for it but it reduced the menstrual period to 3 days and pmdd symptoms lasted less time. When my autoinmune condition started (still disease) doctors where trying to find my diagnostic I stopped all off the labbel medications and supplements for a better diagnostic criteria. I never took it again then my CPR was extremely elevated while on it so I needed not to experiment with meds but just with what Mayo Rochester staff considered was neccesary to stabilize my new condition. One or 2 years after I took my ovaries and uterus out to be cured of pmdd and keep treating just the 1 condition: still disease. I am 4 years on symptomatic remission on a biologic (canakinumab) and it traerá everything including the fatigue and brain fog but usually 4 days before the next shot I become fatigue and with mental burnout. If I was on low dose naltrexone while my autoinmune condition started it should had stopped the symptoms, or prevented the condition and it didnt. If guarfacine is not off the labró I can ask my psychiatrist about it, and if it’s a temporaly use with inmediate action as the other stimulants (4 to 5 days) maybe she agree. Thanks for your help