Hi David. This PN is surely different for all of us at different times in our journeys. For me, my legs get easily fatigued from waking. The muscles around my knees don’t communicate with my nerves or something, so my stride is different. My knees go up and down a little when I walk, but I can’t step up on a curb or climb steps at all without using rails or a walker etc. So the activity of walking fatigues my muscles easily and quickly. That said, it means I need to sit down, not go to bed! It does not make me fatigued as in sleepy. That’s my experience with my PN only, others could easily be different.