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CEA and CA19-9 Results as Predictors of Treatment Outcome
Pancreatic Cancer | Last Active: Aug 16, 2023 | Replies (30)Comment receiving replies
Is there any way they can lower the dose of the modified Folfirinox? Originally my MD was going to give me the full dose until he realized I'm 70. He lowered the first cycle to 80 percent of the full dose, and even at that level it really laid me low with dehydration, diarrhea and nausea. Beginning with cycle 2, the dose was lowered to 60 percent of the full dose. Each cycle has gotten progressively easier in terms of side effects, appetite and even weight gain, and I now have several days at the end of each cycle where I feel pretty much like I used to before all this started.
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Thank you for all your information, very helpful. My husband turned 71 two days after being released from hospital for the Whipple. His first treatment left him so bad, that they did reduce to 80%. Now I wonder what they can lower or take away for #8, without compromising the goal. We will be talking to Dr this week to review everything. I pray that all is well with you and we all can find peace on this journey. Thanks❤️
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I started out at a 50% dose because I have a DPD gene mutation that could make the 5FU toxic. Dose was ramped up to 75% for the second cycle and 100% for cycle 3 which I just completed last week. For what it’s worth I was told by the team at Mass General that data has indicated that efficacy at reduced doses has been proven to be as effective. I have not had any real issues so far. (Knock wood) Eating normal meals and haven’t lost any weight. I drink at least 48 oz of 50/50 Gatorade and water everyday to avoid dehydration. Like you, I feel back to normal after 5-6 days. I’m also 70. Good luck with continued treatments.