@wsbme74 Hello - I was out of touch for a few days visiting family, and just saw your post - yes, according to both my pulmonologist and my recently retired PCP whose practice included many lung patients, the Zithro/Prednisone route can be the best for some of us. I also have asthma with bronchiectasis, and was previously treated for MAC.
I actually use Symbicort (which contains a tiny steroid dose with a long-acting beta agonist) as my daily inhaler. It has reduced my exacerbations over the past year from every 4-5 months to ZERO. It has reduced my Levalbuterol nebs for asthma attacks from at least once a week to TWO in a year. It has reduces my Levalbuterol rescue inhaler use from multiple times a day to once or twice a month.
For 2 1/2 years before that, I had on hand a 7 day steroid packs plus a 5 day Azithromycin pack. I was using them 2-3 times a year.
When I see my Pulmonologist next month, she will need to renew these because they have expired.

Full disclosure - I have also needed to use steroids for 10-30 days to calm inflammatory flares in my body several times as well.

I guess my point is that different things work for different people. This regimen has worked for me for almost 4 years without causing MAC to flare up. And my Dexa says it hasn't affected my bones either.

Sue