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@linda7

I understand what it's like to try to make these decisions. After 18 months on prednisone I was down to 8 mg with good symptom control and no serious side effects. My rheumatologist said that I could not stay on a dose that high and he recommended adding methotrexate which I finally agreed to do. I had read about all the possible side effects plus no alcohol. I told him I had one beer a day and he said I could continue that but I cut back to 3 a week. At first it was brutal. I had every possible side effect but it mellowed out some and my labs are looking good: no liver issues with the methotrexate. I'm about to drop to 5 mg prednisone. So far pain is under control and fatigue is the main issue. I see the doctor soon and I see more decisions in my future. If I can't go to zero on the prednisone am I willing to put up with a 2 drug regime indefinitely? Am I willing to get off the prednisone, which is so effective at controlling sx's, and put up with just methotrexate for 2 years, which is what the doctor wants me to do? If I'm on methotrexate that long I would give up alcohol, which I don't really want to do. Or do I talk him into letting me try just a low dose of prednisone indefinitely? I'm now at 2 years on the prednisone. There isn't much to improve about my diet and exercise habits and I don't have other health issues. Tough things to figure out.

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Replies to "I understand what it's like to try to make these decisions. After 18 months on prednisone..."

Prednisone is known to "redistribute" fat. I have a "beer belly" and people didn't believe me when I said that I didn't consume alcohol.

I had some liver issues while on prednisone. It was noted that I had non-alcoholic fatty liver disease (NALD) on a CT-scan that revealed kidney stones were causing severe abdominal pain and nausea.

I took methotrexate for nearly 2 years in addition to prednisone while my liver enzymes increased. I was progressively getting more nauseated so methotrexate was discontinued even though I was able to decrease my prednisone dose.

I'm having a slight increase in my liver enzymes while taking Actemra but I'm not nauseated. My rhematologist consulted a liver doctor to see if I could continue taking Actemra. The determination was that my elevated liver enzymes on Actemra were more likely caused by NALD.

It wasn't necessary to stop Actemra since I wasn't nauseated or otherwise symptomatic. The liver doctor just said my liver enzymes should be monitored so they don't get too high.