I had to split my dose between morning and night I take them as exact to 12 hours apart as possible. It has helped with the side effects a lot. Are you stretching? Easy stretches can help ease the pain quite a bit. And take Tylenol (or generic) if needed rather than Ibuprophen or other NSAIDS. Call your doctor and leave a message if you still feel lousy. Perhaps you can get on a wait list to see him sooner.