Hi @robindancer5678, Welcome to Connect. Being diagnosed with small fiber polyneuropathy or any neuropathy can make you feel discouraged and disheartened thinking about what is happening and what the future will look like. Hoping your neurologist and/or team of doctors can narrow it down to a cause. Probably the best thing you can do for yourself is to learn as much as you can about your conditions, the associated symptoms and what treatments may be available to provide you with some relief.

You mentioned your symptoms got worse following a Prolia injection. While we wait for other members who may have experience with neuropathy and Prolia injections, I thought I would share this related information I found on the topic.

"Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. If you have low calcium levels, you should not take Prolia."
--- Prolia side effects: What they are and how to manage them: https://www.medicalnewstoday.com/articles/drugs-prolia-side-effects.

Have you discussed the worsening of your symptoms following the Prolia injection with your doctor?