So..so sorry to hear this! It is one of the most painful things that a human can have. I started with two one inch fissures in 1990 and have been dealing with it ever since. Believe me I have learned a few things. Number one does she have a Gastroenterologist? I have a friend whose doctor sewed hers up and after healing had no more problems. So there’s that. I use Anucort 25 mg suppositories and I put neosporin on them at the tip before inserting. I live in Oklahoma and here a doctor made an ointment called Woodwards Ointment. A compound pharmacy can make it and sell you a tube. It’s magic. Botox will also work I had steroid shots. They put me under with great results. I am so sad about your wife that I want to cry. Please ask me anything. You can also use private message by tapping on a person’s name. God bless.