I'm sorry it didn't work out for you. One of the things I liked about LDN is the dose is very customizeable; there are many reports of people who have benefits with less than 4.5 mg, even people who stop at less than a mg, and it can sometimes still be effective. My dad also takes LDN (he has fatigue from an inflammatory arthritis), and his dose ended up being 4.75 mg. When he was taking 5 mg, he was really overactive, bordering on anxious, which led us to scale it back. It's interesting how such a small change can make a difference.