the difference between Anoro and Breo is that Anoro does not contain a steroid (fluticasone) like Breo does instead Anoro replaces the steroid with an anticholinergic called Umeclidinium (Breo does not have an anticholingeric). Both Anoro and Breo contain Vilanterol a long acting bronchodilator. I personally try to avoid anticholinergics because they are drying and I want my cough to remain productive. I have no clue whether this is medically necessary or I made it up! (An example of a common anticholinergic is Benadryl.)