I had the original formulation of Folfirinox that was 20% higher concentration than (m)Folfirinox in use since 2018. I had 24 cycles in groups of six with alternating groups of just 5-FU/Leucovorin to lessen the cumulative effects of neuropathy from oxaliplatin. That alternate dosing helped in the peripheral neuropathy from becoming severe and permanent. It resolved but took several years.