I have had chronic constipation for more years than I can remember. I have seen dozens of GI docs and had every test that there is for my specific condition. I have been on Trulance which worked well for 4 years and then suddenly stopped working. I tried Linzess, motegrity, amitiza all with horrible side effects. I would get terrible bowel spasms and couldn't get comfortable and literally out of my mine with pain. Fast forward to where I am at today. My GI doc prescribed Ibsrella 50. I was always a coffee drinker, not excessive, just one cup in the morning. I decided to give up coffee or anything with caffiene completely and things started to move every day and no side effects. I believe is that the coffee was making my muscles tight and my whole body jittery which made the constipation worse. I am doing meditation every day, and it helps me so much...relaxed mind, relaxed body. I hope this helps someone.