The first indication that I knew something was not right was the fatique. It took two years to be diagnosed. I took the ‘3’ for three years. No one ever told me that one of the three would affect my sight and one would affect my hearing. I see my optometrist regularly and he knew which one affected my sight but after three years my hearing has taken a huge hit. My sight - now corrected it is 30/20 which I was assured is still not bad. However I cannot hear anyone sitting 3 feet from me now. I would recommend you get baseline tests before beginning the big 3.

Hi Arlo, the prospect of the 3 antibiotics scared most of us. I discussed it at length with my primary because the pulmonologist was not approachable. We decided that the severity of my cough and fatigue plus the many nodules in my lungs, and having asthma as well as bronchiectasis tipped the scales toward treatment. IF we had known then about 7% saline, and IF my lung CT was not so bad, we might have elected to wait and see. For the record, while the Big 3 were tough, I made it through with no effect on hearing or vision.
Have you read the latest recommendations from the Lung Assn and NJH on when to treat? Have you asked your pulmonologist why they are recommending treatment now? What did they see in the bronchoscopy and CT that say "treat now" vs "watch and wait"? Once an infection progresses to cavitary status, the treatment is less likely to be successful, the possibility of needing surgery increases and life expectancy decreases.
Please don't let fear of possible side effects drive your decision.
Sue