I have had ankle swelling for years. I think it started from a mosquito or maybe a spider bite on left ankle. X-rays and MRIs show fluid. Pain starts after walking several times a month. I have done physical therapy and stopped walking. Pain gets better and I start walking, pain comes back. Dr. gave me ankle brace which helps a lot. The only solution is to have a surgery done. My leg is swollen several areas but it is not from kidneys. Drs said it's due to ankle being inflamed. I don't like to take anti inflammatory drugs. These drugs are not safe.