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Leoprolide (Lupron) shot monthly or removal of ovaries?

Breast Cancer | Last Active: Jul 28 5:47pm | Replies (37)

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@monimoa

For those of you who are pre-menopausal and thinking about having your ovaries removed, this message is for you. Here’s my story:

My first breast cancer was found when I was 43 and I had a double mastectomy. No chemo or radiation was needed (clear margins and negative sentinel node biopsy). The doctors recommended Tamoxifen, but I chose not to take it after carefully considering my specific risk factors.

8 years later (last September), cancer was found in my lymph nodes on the same side that the first cancer was found. After 16 rounds of chemo and when it came time for my axillary dissection, I elected to have my ovaries removed.

All of my doctors—both my awesome local doctors and the doctors at the Mayo that I reached out to for a second opinion—said that having ovaries removed was totally OK. They said that if I were 10 years younger, they would NOT have recommended it because of the significantly higher risks to developing dementia and other health issues that are associated with ovary removal pre-menopause. You can find this research with a quick Google search.

Being 51 years old, I’m at the average age for the onset of menopause. So electing to remove my ovaries was a no-brainer. For those of you who are much younger, I encourage you to look at the research. I didn’t find this research when I searched for oophorectomy vs. Tamoxifen. I had to input key words to include dementia (e.g. “oophorectomy, dementia”).

On a side note (and surprising to me) as I started considering an oophorectomy, I was advised to take an aromatase inhibitor as the last step in my treatment plan due to the fact that fat cells contribute to estrogen production. Removing ovaries was not enough to starve any potentially remaining cancer cells of the estrogen they need. But I felt more comfortable with the side effects of the AI vs. potential complications of my specific risks taking Tamoxifen.

Best wishes to you all!

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Replies to "For those of you who are pre-menopausal and thinking about having your ovaries removed, this message..."

If you felt comfortable taking Tamoxifen would the drs have been ok w that vs the AI or did they specifically want you to take an AI since you had oophorectomy?

This is great info and very helpful! I am in a similar situation. I'm 47, premenopausal, and my oncologist strongly prefers AIs to Tamoxifen. I have been getting monthly Zoladex injections to put me in a menopausal state so I can take an AI, but my doc keeps recommending getting my ovaries removed instead of continuing the Zoladex. I had trouble with anastrozole and letrozole causing trigger finger and joint pain, so I switched to Tamoxifen, but that caused unbearable depression and anxiety. Thankfully, the last AI, exemestane, has been great and has not caused the trigger finger or joint pain. I have been on the fence about removing my ovaries vs. continuing Zoladex. I'm really afraid of messing with what is working! I worry that an oophorectomy will cause irreversible side effects. Thank you so much for sharing your experience!