@wpglea I had mastectomies and went "flat." I switched from generic anastrazole to brand name letrozole (Femara) and tolerated it quite well. That's just me. But it is an option to try different AI's and different manufacturers.

For bones they will offer Reclast during treatment. I have recently been offered a test dose of 20%, 1 mg vs the full 5mg. If I tolerate that, I can do a half dose, which is supposed to be just as effective. Good luck!