Jerrysgirl3, I was only on 100 mg (1/2 of a 200 mg tablet) once a day to start with. I am ULTRA sensitive to medication. Did great for about 5 weeks and then started with wierd headaches, facial twitching, nausea & palpitations. I am now taking 100 mg every other day and weird headaches continue & mild palpitations. HOWEVER, it has helped my pain and inflammation greatly. I would like to come off of it to be honest. I see rheumy this month for advice. Blessings.....