@ray666 - Ray, on your comment about the ALA - I too was on 1200 mg daily for about 2 years and did not see much of an improvement. Or would the PN be worse without the ALA?? I mentioned to my doc at one time that I feel the progression of PN takes place in what I refer to as steps. Unfortunately, none of the steps are upward, they are going in the opposite direction. I feel my numbness is about the same as it was a year ago, but the balance is definitely worse...which I have noticed will sort of hold at one level for 6 - 9 months and then, another step downward. The cause of the PN (good luck!) could also dictate the speed of the progression. I went to 600 mg of ALA for a half a year, 4 months ago, went back again to 1200 mg daily. Now, I'm taking the R-ALA. No noticeable difference but it is not worse in past 4 months. So, not getting worse in 4 months....is that an improvement? Not sure if others have these "steps" and when I see my neuro doc in Sept., this will be discussed. My non-medical thinking is this, if ALA or R-ALA can slow down progression, isn't that a clue for stopping it? Not a cure, just stabilize it. Best of luck with your EB-N5 as well.