I was on Actonel for a little over a year, but some of my numbers got worse; that's why I'm on Tymlos now. I could tolerate Actonel (mostly), but it wasn't working. I take the shot in the evening. I've settled on this after going back and forth from morning to evening. The reason I do it at night is that I get those awful heart palpitations from the shot. The Tymlos nurse (you can get assigned one from the Tymlos website) recommended that I lie down and elevate my legs to lessen the effect. It absolutely works. So, I figured if I was going to be lying down, it might as well be in the evening. It has turned my shot, which takes seconds, into a "thing" that can last 30 minutes. I don't feel any side effects by morning.