Haven't been on it long. Takes about a week to kick in from a SE perspective. Manageable though, especially with a solid exercise regimen. Orgovyx studies shows less SE's and quicker T recovery after stopping compared to Lupron. Less than have that CV SEs than Lurpron as well which was important to me with my CAD history. The fact that it's a daily oral med was a big draw for me. If I develop any SEs I just can't deal with, I can stop taking it. If I get a single 6 month dose injection of Lurpon, I can't undo that. I've seen others post about their Orgovyx experience so check them out as well.