I don't know a lot about B6, except when I got this PN 7 years ago, they said to make sure B12 stayed good, and a little extra didn't hurt. So I took a B Complex vitamin to get all the B's. My primary Neurologist sent me for a PN consult to 2 medical universities early on, and by the time I got to the Duke appointment, my B6 was higher than standard. The doc first thought she found my "cause" but all of my B's were fine when the PN started 4 months earlier, it only went up because I intentionally added the daily supplement. So she told me to stop that, and only add trace amounts of B6 if it was part of another vitamin (like One A Day) but to not try to increase B6.