I've been taking Ziprasidone for approximately fifteen years for major clinical depression and being bipolar. I did this because I am also taking Effexor and Lamictal. They helped but I still was having problems. I was taking 20 mg ziprasidone in the morning and 80 mg at night.This med was so successful to get my mental problems in check/ My doctor agreed to quit taking the 20 mg dose several months ago and I am doing fine. I have several dry mouth I have to take medication for it. I think the Ziprasidone is the cause but it is so hard to tell because I take a lot of meds.