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Question about PMR in addition to other autoimmune disorders?

Polymyalgia Rheumatica (PMR) | Last Active: Jun 3 2:12pm | Replies (32)
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@nyxygirl

@dadcue HLA ( human Leukocyte antigen) is also referred to a major Histocompatibility complexes I and II .

So in the figure below for GCA - you can see that DC cells ( dendritic cells) 'present antigen' to T-cells have MHC II on the surface . HLA DR -04 allele is (an MHC II) is mentioned often in studies of PMR patients.

I worked in the field of xenotransplantation for many years -- transplant biology and many others fields have worked out the immune cells of these pathways ! it is really quite mind boggling !

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Replies to "@dadcue HLA ( human Leukocyte antigen) is also referred to a major Histocompatibility complexes I and..."
DadCue | @dadcue | Jul 4, 2023

I wish to understand everything but it very quickly becomes mind boggling.

Xenotransplantation sounds like a fascinating field to be involved in.

I'm interested in the innate immune response because I was diagnosed with reactive arthritis some 30 years ago. My immune system overreacts to infections.

Then there is the adaptive immune system:

"The adaptive immune system takes over if the innate immune system is not able to destroy the germs. It specifically targets the type of germ that is causing the infection."
https://www.ncbi.nlm.nih.gov/books/NBK279396/#:~:text=The%20innate%20immune%20system%20is,the%20%22nonspecific%22%20immune%20system.
I barely understand the information contained in the above link.

The "immune memory" concept is now the thing that worries me the most. My rheumatologist said that my immune system isn't likely to "forget" what it has been attacking for all these years. He was referring to how my immune system has been attacking me. He thinks immune memory is a characteristic of autoimmune conditions that are allowed to persist for too long. He said an immune memory is detrimental when one has an autoimmune condition.

My immune system is completely deranged which is all I know.

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