@paulagcl and. @dadcue -- Please look at the slides in PMRandIl6.com - https://www.pmrandil6.com/resources/. scroll down to find the videos
The two biologicals tocilizumab and sarilumab are anti-IL6-receptor antibodies . this site is from sanofi /regeneron and is not an advertisement* for Kevzara (sarilumab)!- . there are two videos - nicely done for lay people .
* that said - the video about the contraindications of Prednisone is practically an advertisement for wanting to try sarilumab !! : )

The American college of Rheumatology Meeting is in Nov- it will be interesting to see what abstracts there are for PMR and who might be doing (more) basic research about the immune-cell pathways.

In 2022 this paper was published about GCA -- Fig 3 shows what tocilizumab is blocking.
Review
New Insights into the Pathogenesis of Giant Cell Arteritis: Mechanisms Involved in Maintaining Vascular Inflammation

In 2022 - this paper review was published about PMR - i really like the Lunberg fig with the shoulder girdle ! An update on polymyalgia rheumatica
Ingrid E. Lundberg. J Intern Med. 2022;292:717–732