Hello @thedaleys, Welcome to Connect. Yikes! 15 months is a long time to be suffering with that kind of pain and no relief. While we wait for others with experience to respond to your discussion, I thought it might be helpful to read through the following discussion to see what other members have shared.

--- Anal fissure: What helps it heal?: https://connect.mayoclinic.org/discussion/anal-fissure/

Mayo Clinic has some information on treatments here - https://www.mayoclinic.org/diseases-conditions/anal-fissure/diagnosis-treatment/drc-20351430. Since your wife has had to endure the pain for 15 months, has her doctor offered any other suggestions or surgery?