I refuse to take the big 3. It would be conflicting with other autoimmune diseases I have. I do percussion vest and 7% saline 30 minutes twice a day. I am currently in hospital with pleurisy 5 days now. But, my last visit with pulmonologist 3 months ago showed nothing got better and nothing got worse. I was happy with that. Now with this new problem, I don't know. I just cannot do the big 3.