I was first diagnosed with HR+HER2- bc in 2018. Double mastectomy, chemo and radiation after which I was prescribed Anastrozole. My onco was persistent about getting me into a Kisqali (Ribociclib) study for women in my situation (high risk but no metastis) that I hesitantly signed up for. In 2021 I had eye infections in both eyes, 6 months apart, that left permanent ulcers on my corneas so am now legally blind. I have been fitted with scleral lenses that really help with vision but have lots of issues themselves. I immediately stopped taking the Kisqali after the 2nd infection. Unfortunately I was diagnosed with stage 4 metastatic bc in Dec 2022 and started a regimen of Fasoldex, Xgeva and Verzenio in January 2023. Diarrhea with the Verzenio has been problematic. More bad news this June, a pet scan showed the Verzenio was no longer effective at keeping the cancerous cells in my lung at bay so I am being scheduled for chemo treatment using Abraxane with the hopes this will keep the cancer from advancing. All this to say if your cancer is not metastatic and you are not high risk, my personal feeling is to not add the risk of infection and side effects of Verzenio or any similar drug.