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Question about PMR in addition to other autoimmune disorders?

Polymyalgia Rheumatica (PMR) | Last Active: Jun 3 2:12pm | Replies (32)
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@dadcue

I think it is best when doctors obtain as much information that they can. There are some limits to what can be done with the information.

I remember when I was originally diagnosed with reactive arthritis over 30 years ago. The doctor mentioned a genetic test call HLA-B27. He said it wouldn't change his diagnosis whether it came back positive or not. I just politely said that I would be interested in knowing what it was even though I had no clue what HLA-B27 was all about.

My HLA-B27 came back positive and it probably didn't change anything. However my being HLA-B27 positive was plastered all over my medical records. It meant something to the doctors that followed.

https://www.healthline.com/health/hla-b27-antigen

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Replies to "I think it is best when doctors obtain as much information that they can. There are..."
nyxygirl | @nyxygirl | Jul 3, 2023

@dadcue HLA ( human Leukocyte antigen) is also referred to a major Histocompatibility complexes I and II .

So in the figure below for GCA - you can see that DC cells ( dendritic cells) 'present antigen' to T-cells have MHC II on the surface . HLA DR -04 allele is (an MHC II) is mentioned often in studies of PMR patients.

I worked in the field of xenotransplantation for many years -- transplant biology and many others fields have worked out the immune cells of these pathways ! it is really quite mind boggling !
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