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Stage IV

Pancreatic Cancer | Last Active: Aug 18, 2023 | Replies (29)

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@mimimmx

I had terrible nausea after my first folfirinox infusion. Lost 10 lbs in 10 days. My team did several things that has substantially helped. First, they have added saline infusions on the day of the chemo, on the day the pump is disconnected and in day five after the infusion. They also prescribed Olanzapine which has been a game changer (reduce nausea, increase appetite). On day of infusion they also are providing anti nausea treatment. Finally, I take Zofran 3x per day and compazine 2x per day. Since these adjustments, I have not lost more weight and I am able to work through out the two weeks after the infusion.

I receive my fourth infusion tomorrow. Hope this helps.

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Replies to "I had terrible nausea after my first folfirinox infusion. Lost 10 lbs in 10 days. My..."

Thank you for this information @mimimmx. He lost about 12 pounds in the few days following treatment. As soon as he started feeling better, he has put 8 pounds back on. He's eating at least 2000 calories a day and drinking at least 1800ml water per day. On his day of chemo, he did have anti nausea and fluids prior to infusion. When they disconnected his 5FU pump 2 days later, they gave him more IV fluids and anti-nausea. They wanted to do more fluids 5 days later but he didn't at all appear dehydrated and he was eating and drinking like a champ. He got really annoyed because on his week off of chemo, he doesn't want to go into an infusion center...which I understand that. They recently gave him Olanzapine as well. Do you stay on the Olanzapine daily (they told him to take it at night) in addition to the compazine and zofran every day after infusion up until your next one OR only when nausea presents himself? You have been super helpful. Sounds like you are doing great during your infusions? Are you seeing someone at the Mayo Clinic?