I’ve only taken it for a little less than two weeks. 3mg..it is a compounded drug and comes in a way that you can split in half or in quarters. I started on 1/4 for a week and noticed less pain in my legs at night right away. I am now taking 1/2 and even less pain now. My PCP didn’t give it to me and the Lung Dr. didn’t have a clue…so I found a new Doctor who thinks outside the box ..she so far is awesome.