OMG they tested me Five times for LUPUS! Why is that usually a go to for doctors! I think you’ll find that most of us had to start with a higher dose of prednisone. I started at 40mg but I couldn’t walk. My legs felt like they were in asked in cement. I also did not fit the normal profile. Mine was totally in thighs, hips, lower back. Inflammation markers were off the charts though. I started pred in December and am now down to 12.5mg along with methotrexate. I have the sweats and sometimes, like you, feel hot. Are the hot flashes new since you started taking prednisone? Or did you have before?