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Husband had Whipple surgery and chemo: He's uncomfortable

Pancreatic Cancer | Last Active: Oct 1, 2023 | Replies (117)
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@gamaryanne

So you believe Gemzar was ineffective due to the gene mutation you have?
I have KRAS G12d.
Fulfurinox worked very well for me. Now I am being encouraged to “try” Gemzar but I would much prefer doing what I know worked.

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Replies to "So you believe Gemzar was ineffective due to the gene mutation you have? I have KRAS..."
stageivsurvivor | @stageivsurvivor | Jun 24, 2023

I am one of 10% of the patient population that does not produce an enzyme in the liver to break the drug down into its toxic metabolite. That came to light after the first scan after three months of treatment.

Gemzar is the first drug that was approved in 1995 for treating pancreatic cancer by the FDA. It is more effective when combined with an additional chemo agent such as Abraxane or cis-platin.

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lvtexas | @lvtexas | Jun 26, 2023

Did oncologist say why? How many Folfirinox cycles have you had? 12 is listed as max for toxicity? And there is a worldwide shortage of platinum so the oxyplatin is short or not available.

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