I am now 8 years into the battle. Surgery with clean margins but one year later PSA spiked. Then radiation and Lupron combined with two years of 150mg/day Bicalutimide. psa undetectable but then PSA then returned after 14 months. Treated angain but only get 6 month undetectable. We are now doing 3 month intermittent treatments of Lupron and 50mg/day Bicalutimide. This gives my body time to recover a bit for my bones, liver and muscles. The first time my PSA stayed undetectable for 14 months, but we found three very small tumors in my pelvic lymph nodes. Treated again and only got 6 months. Treated again this week and will check PSA every two months going forward. Our plan is to treat when PSA is above 2.0. Keep doing it till I become resistant and then either find an alternative drug or go to continuous treatment to keep the PSA below 2.0. I am tolerating it all well with moderate hot flashes. But not sure what I can do about then belly fat I am accumulating. Hate that, but it’s vanity.