Hi mariajean03, I am so sorry I did not answer earlier. Yes, I only had one Reclast infusion in 2014. I then continued on Fosamax for 4 more years. That worked for me. This held me for a number of years without taking further drugs. Now In 2023 my bone density has fallen to a level where I need drugs again. My research now also made me aware of how many different drugs I and other people take which contribute to bone loss. Unless you accidentally drip over it you would never know. Ps I was told by my physician, that once you are stable , the drugs in your bones will hold you for a while without needing further drugs.