My husband's CA 19-9 was very very high when he was originally diagnosed (34,000!). But his tumor and liver mets were all very small. After 4 rounds of Folfironox they had dropped to 5,000. He just completed his 7th round and we are waiting results - along with agressively incorporating everything we can learn regarding a metabolic cancer-starving protocol consistent with Jane McLelland's book "How to Starve Cancer".